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November 2019 Edition
Welcome to the first edition of The Pharmer’s Almanac newsletter!
Our goal is to help foster community across PharmTox students, faculty and staff by highlighting relevant events, departmental achievements, and what’s on the horizon.
In this edition, we highlight recent news from our Faculty members, Graduate and Undergraduate Education announcements, upcoming events, and recent publications.
Have an event, story, award or publication you’d like to share? Let us know by December 2nd to have it included in our December newsletter.
Happy Reading!

Awards & Recognitions

University of Toronto Pharmacology & Toxicology Professors Susan R. George and Brian O’Dowd have been awarded the prestigious Prix Galien 2019 award, referred to as the Nobel Prize of Pharmaceutical Research. Read more

In the News

Biomarker Associated with Chronic Stress and Anxiety Found in Higher Levels in Long-Term Young Cannabis Users

Faculty members, Dr. Romina Mizrahi, Dr. Pablo Rusjan and Dr. Jeffrey Meyer, along with PhD candidate Jeremy Watts among the researchers involved in this groundbreaking study.
Making a global impact: Four U of T projects receive Connaught Global Challenge Award

Dr. Ana Cristina Andreazza and her team win one of the four Connaught Global Challenge Awards. The award will go towards enhancing mitoNET, a network for mitochondrial research.

Graduate News

Graduate student mentorship program: Sign up to be a mentor or mentee here by Monday, November 18
Graduate Pharmacology Weekly Round-Up: In case you missed it, here's the last round-up of grad-related events
Cookie decorating during coffee hour: Thursday, November 28 at 4pm in the lunchroom (MSB 4243)
Holiday door decorating contest: Pictures need to be submitted to Deeba by Tuesday, December 10, 5pm

Undergraduate News

Want to show off your Pharmacology Pride? Want to look your best for those PharmTox events? Then you're in luck! Because the PTSA is currently selling official U of T Pharmacology & Toxicology Sweaters and Crewnecks.

Reserve yours by Dec 4th. Crewnecks will be delivered early next semester.
Feeling stressed? Pop by the PTSA's weekly lounge days! These are held every week Mondays from 3-5pm, and Tuesdays at 11am - 2pm in MSB 3378!

Drop by for snacks, games, and to just chill & de-stress with friends or other members of your community! 
To join our community and be informed of upcoming events, please follow us on Facebook. If you have any questions, we can be reached there as well!

For those of you currently in second year, head over and check out the Pharmacology & Toxicology Class of 2022's Facebook page.

Upcoming Events

Career Mentor Night

Thursday, January 16, 2020 | 5:30 - 8:00 PM
Faculty Club, Main Dining Room (41 Willcocks St)

Save the date! The 2020 Career Mentor Night will be held on Thursday, January 16th at the Faculty Club. Details to follow.

Publication Highlights

Attwells S, Setiawan E, Wilson AA, Rusjan PM, Miler L, Xu C, Hutton C, Husain MI, Kish S, Vasdev N, Houle S, Meyer JH. Replicating predictive serum correlates of greater translocator protein distribution volume in brain. Neuropsychopharmacology. 2019 Nov 4;. doi: 10.1038/s41386-019-0561-y. [Epub ahead of print] PubMed PMID: 31683271.

Bian Q, McAdam L, Grynpas MD, Mitchell J, Harrington J. Increased rates of vitamin D insufficiency in boys with Duchenne Muscular Dystrophy despite higher vitamin D3 supplementation. 2019. Global Pediatric Health. 6: 2333794X19835661. 

Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF. Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities. Clin Pharmacol Ther. 2019 Nov 6;. doi: 10.1002/cpt.1664. [Epub ahead of print] PubMed PMID: 31696505.

Crosby M, Riddick DS. Suppression of hepatic CYP3A4 expression and activity by 3-methylcholanthrene in humanized PXR-CAR-CYP3A4/3A7 mice. 2019. Drug Metab. Dispos. 47: 279-282.

Darwish L, Nquyen M, Saleem M, Eakin KA, Herrmann N, Sugamori KS, Oh PJ, Yang J, Mitchell J, Lanctot,KL, Swardfager W. Lower serum osteocalcin concentrations in patients with type 2 diabetes and relationships with vascular risk factors among patients with coronary artery disease. 2019. Journal of Diabetes Complications. 33 (5): 390-397.

El-Boraie A, Taghavi T, Chenoweth MJ, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Nollen NL, Benowitz NL, Tyndale RF. Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity. 2019. Addiction Biology. [Epub ahead of print]  (PMID: 30815984)

Krance SH, Wu CY, Zou Y, Mao H, Toufighi S, He X, Pakosh M, Swardfager W. The complement cascade in Alzheimer's disease: a systematic review and meta-analysis. Mol Psychiatry. 2019 Oct 18;. doi: 10.1038/s41380-019-0536-8. [Epub ahead of print] PubMed PMID: 31628417.

Mann MK, Franzoni I, de Freitas RF, Tempel W, Houliston S, Smith L, Vedadi M, Arrowsmith CH, Harding RJ, Schapira M. Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain. J Med Chem. 2019 Oct 30;. doi: 10.1021/acs.jmedchem.9b00988. [Epub ahead of print] PubMed PMID: 31663737.

Matheson J, Sproule B, Di Ciano P, Fares A, Le Foll B, Mann RE, Brands B. Sex differences in the acute effects of smoked cannabis: evidence from a human laboratory study of young adults. Psychopharmacology (Berl). 2019 Oct 22;. doi: 10.1007/s00213-019-05369-y. [Epub ahead of print] PubMed PMID: 31637452.

Peng AR, Swardfager W, Benowitz NL, Ahluwalia JS, Lerman C, Nollen NL, Tyndale RF. Impact of Early Nausea on Varenicline Adherence and Smoking Cessation. 2019. Addictions. [Epub ahead of print] (PMID:31502736) 

Tolledo EC, Miksys S, Gonzalez FJ, Tyndale RF. Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: effects on activity and drug response. Br J Pharmacol. 2019 Oct 24;. doi: 10.1111/bph.14884. [Epub ahead of print] PubMed PMID: 31648367.

Yoon SH, Grynpas MD, Mitchell J. Growth hormone increases bone toughness and decreases muscle inflammation in glucocorticoid-treated mdx mice, model of Duchenne muscular dystrophy. 2019. Journal of Bone and Mineral Research. 34(8): 1473-1486

Yoon SH, Grynpas MD, Mitchell J. Intermittent PTH improves bone and muscle in glucocorticoid treated Mdx mice: A model of Duchenne muscular dystrophy. 2019. Bone. 121:232-242

See other recent publications.

Send us the PMID of your publication if you'd like it highlighted here!

We'd love to hear from you!

Have an event, story, award or publication you'd like to share? Let us know by December 2nd to be featured in the next issue.
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