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BTP Quarterly Update

September 18, 2019

The mission of the University of Minnesota Brain Tumor Program (UMBTP) is to continually distinguish itself as a national leader in the field of neuro-oncology by combining the principles of outstanding clinical care and education with cutting edge research.

The group consists of many dedicated researchers and clinicians of numerous disciplines and specialties. These disciplines and specialties include - but are not limited to - cancer genetics, neuro-oncology, neurosurgery, pharmacy, biomedical engineering, and veterinary medicine. 

Here's what we've been up to for the last few months:
"Shop Local, Support Cancer Research During Childhood Cancer Awareness Month, " highlighted on MHealth blog, August 30, 2019. See the article for local partners who are supporting our Childhood Cancer Fund during the month of September!
"Distinguished Surgeon and Scientist, Andrew Venteicher, Joins M Physicians, " highlighted on MHealth blog, August 5, 2019.
Clark Chen, MD, PHD was highlighted in a 5 EyeWitness News video "First in the world intraoperative MRI surgical suite at U of M Medical Center," July 24, 2019. 
Mike Olin and Chris Moertel were highlighted in Children's Cancer Research Fund article "Upcoming Clinical Trial Takes Aim at Brain Tumors," June 27, 2019. 
Clark Chen, MD, PHD was highlighted in a Kare11 News video "New drug helps surgeons spot brain tumors by turning them pink," June 27, 2019. 

CONGRATULATIONS

Congratulations to the following BTP Members who were identified as Top Doctors by Minnesota Monthly Magazine
  • Neurosurgery
    • Matthew Hunt, MD, FRCS
    • Daniel Guillaume, MD, MS
    • Andrew Grande, MD
    • Ramachandra Tummula, MD
  • Neuro-Oncology
    • Christopher Moertel, MD
  • Neuro-Radiology
    • Frederick Ott, MD
  • Radiation Oncology
    • Kathryn Dusenbery, MD
    • Christopher Wilke, MD, PhD

PRESENTATIONS

Lester Drewes, PhD, presented a poster entitled "Brain Endothelia Bioenergetics via Extracellular Flux Analysis" at the Experimental Biology 2019 Meeting, Orlando, FL, April 2019.

Lester Drewes, PhD, presented a poster entitled "Bioenergetic signatures of brain endothelial cells" at the Cold Spring Harbor Conference on Blood-Brain Barrier, Cold Spring Harbor, NY, April 2019.

Lester Drewes, PhD, presented a poster entitled "Development of the first 
18F-labeled MCT1/MCT4 lactate transport inhibitor: Radiosynthesis and preliminary in vivo evaluation in mice" at the International Society of Radiopharmaceutical Sciences (ISRS), Beijing, China, May 2019. 

Lester Drewes, PhD, presented a poster entitled "Preclinical incorporation Dosimetry of [F-18]FACh a no
vel 18F-labeled MCT1/MCT4 lactate transport inhibitor" at the Society of Nuclear Medicine and Molecular Imaging Meeting (SNMMI), Anaheim, CA, June 2019.

Lester Drewes, PhD, presented a poster entitled "Bioenergetic Signatures of Human Brain Endothelial Cells" at the Cerebral Vascular Biology 2019 Meeting, Miami, FL, June 2019.

David Largaespada, PhD, gave presentation entitled "Using Transposons to Study Cancer" at the FASEB Mobile DNA Meeting, Palm Springs, CA, June 2019. 

Kyle Williams, PhD, was nominated as a Young Investigator and selected to speak about his work on "Building models for therapeutics discovery for NF1-related tumors and malignancies" at the Society for Neuro-Oncology Young Investigator's Forum, Atlanta, GA, July 2019.

GRANTS

Lester Drewes, PhD, received grant entitled "Dementia, Diabetes and Brain Endothelium" from the Memory Keepers Medical Discovery Team- University of Minnesota, August 2019. 

Mike Olin, PhD, received grant entitled "Targeting Multiple Immune Checkpoints with a Single Checkpoint Inhibitor: Implications for Immunotherapy Against CNS Cancer" from the Musella Foundation, August 2019. 

Mike Olin, PhD, received grant entitled, "Targeting multiple checkpoint blockades with a single peptide inhibitor" from the Children's Cancer Research Fund, August 2019.

Chris Moertel, MD, and Mike Olin, PhD, received grant entitled, "Employing the CD200 Checkpoint to Optimize Immunotherapy for Pediatric Brain Tumors" from the Hyundai Hope on Wheels Foundation, September 2019. 


Andrew Venteicher, MD, PhD, received a Career Awards for Medical Scientists (CAMS, a NIH NINDS K12 grant) entitled "Uncovering drivers of immortality in human CNS tumors" from the Burroughs Wellcome Fund, September 2019.

PUBLICATIONS

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, Gonzalez HM, Yuan C, Lockhard SN, Hughes TM, Chen CLH, Sachde P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GH, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Darkof F, Muller M, Breteler MMB, Roman GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. "Vascular dysfunction-The disregarded partner of Alzheimer's disease." Alzheimers Dement. 2019 Jan; 15(1): 158-167. https://doi.org/10.1016/j/jalz.2018.07.222

Keep RF, Jones HC, Drewes LR. "The year in review: progress in brain barriers and brain fluid research in 2018." Fluids Barriers CNS. 2019 Feb 5; 16(1): 4. https://doi.org/10.1186/s12987-019-0124-y

Jonnalagadda S, Jonnalagadda SK, Ronayne CT, Nelson GL, Solano LN, Rumbley J, Holy J, Mereddy VR, Drewes LR. "Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors." Oncotarget. 2019 Mar 22; 10(24): 2355-2368. https:/doi.org/10.18632/oncotarget.26760

Wang L, Ning J, Wakimoto H, Wu S, Wu CL, Humphrey MR, Rabkin SD, Martuza RL. "Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells." Mol Ther Oncolytics. 2019 Mar 29; 13: 58-66. https://doi.org/10.1016/j.omto.2019.03.008

Ippen FM, Alvarez-Breckenridge CA, Kuter BM, Fink AL, Bihun IV, Lastrapes M, Penson T, Schmidt SP, Wojtkiewicz GR, Ning J, Subramanian M, Giobbie-Hurder A, Martinez-Lage M, Carter SL, Cahill DP, Wakimoto H, Brastianos PK. "The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases." Clin Cancer Res. 2019 Jun 1; 25(11): 3374-3383. https://doi.org/10.1158/1078-0432.CCR-18-3049

Williams LA, Spector LG. "Survival Differences Between Males and Females Diagnosed with Childhood Cancer." JNCI Cancer Spectr. 2019 Jun; 3(2): pkz032. https://doi.org/10.1093/jncics/pkz032

Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA. "Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis." Cell Stem Cell, 2019 Jun 13. https://doi.org/10.1016/j.stem.2019.05.013

Sadaghzadeh M, Moldovan RP, Fischer S, Wenzel B, Ludwig FA, Teodoro R, Deuther-Conrad W, Jonnalagadda S, Jonnalagadda SK, Gudelis E, Sackus A, Higuchi K, Ganapathy V, Mereddy VR, Drewes LR, Brust P. "Development and radiosynthesis of the first  F-labeled inhibitor of monocarboxylate transporters (MCTs)." J Labelled Comp Radiopharm. 2019 Jun 30; 62(8): 411-424. https://coi.org/10.1002/jlcr.3739

Ramkissoon A, Chaney KE, Milewski D, Williams KB, Williams RL, Choi K, Miller A, Kalin TV, Pressey JG, Szabo S, Azam M, Largaespada DA, Ratner N. "Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK." Clin Cancer Res. 2019 Jul 1; 25(13): 4117-4127. https://doi.org/10.1158/1078-0432.CCR-18-3224

Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H, Rabkin SD. "Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma." Nat Commun. 2019 Jul 2; 10(1): 2910. https://doi.org/10.1038/s41467-019-10993-5

Wang B, Wu ZH, Lou PY, Chai C, Han SY, Ning JF, Li M. "Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN." Cell Oncol (Dordr). 2019 Jul 22. https://doi.org/10.1007/s13402-019-00461

Picariello HS, Kenchappa RS, Rai V, Crish JF, Dovas A, Pogoda K, McMahon M, Bell ES, Chandrasekharan U, Luu A, West R, Lammerding J, Canoll P, Odde DJ, Janmey PA, Egelhoff T, Rosenfeld SS. "Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner." Proc Natl Acad Sci USA. 2019 Jul 30; 116(31): 15550-15559. https://doi.org/10.1073/pnas.1902847116

Liu CJ, Shamsan GA, Akkin T, Odde DJ. "Glioma Cell Migration Dynamics in Brain Tissue Assessed by Multimodal Optical Imaging." Biophys J. 2019 Aug 15. pii: S0006-3495(19) 30696-4. https://doi.org/10.1016/j/bpj.2019.08.010

Cornax I, Pluhar GE, Clark HB, O'Sullivan MG. "Oligodendroglioma with neruonal differentiation in two boxer dogs." Journal of Comparative Pathology, in press. 

Olin MR, Xiong Z, Ampudia Mesias E, Pluhar GE, Rathe S, Largaespada DA, Sham Y, Moertel CL. "CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy." Clin Cancer Res, accepted. 

Past Events

Elizabeth Neil, MD, was invited to speak at the Humor to Fight the Tumor Annual Gala, September 7, 2019.

Upcoming Events

October 10 - BTP Data Club, Lindsay Williams, PhD
October 12 - ABTA's BT5k at Como Park
                      Register Here
November 14 - BTP Data Club, Katelyn Swanson
December 12 - BTP Data Club, Jian-Ping Wang, PhD

Highlights & Recognitions

Mike Olin, PhD was promoted to Associate Professor in the Department of Pediatrics, July 2019.

Cade McDonald successfully defended his M.S. degree in Integrated Biosciences, July 2019.

Elisabet Ampudia-Mesias, PhD, graduated from the Comparative and Molecular Biosciences graduate program, receiving her PhD, August 2019.
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