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All about Josh's First video Blog I wanted to talk to you guys about GA1 and show you what it was like for me as as baby and show you guys what its like for me a young boy and what its like to be a adult with GA1 and show you guys that I know how to have a good time too. Just watch through the first part, where my cousin and I lived together, then it goes to when I was 21 months old and got sick from GA1. I Wanted to do all of this in one video. I Know some of you may not like or get wrong ideas about the video by the intro but the next one will be a lot better. The next one I am going to try to do me walking around and some other stuff.Some of this stuff in this video is just for fun and to make it longer. This video is about me a few years ago and whenever I first got sick with GA1. So can I get some likes.
This is my second video blog. In this video I will talk about how I met Stormie and what happen to her and how handled what happen to her. I will also talk about me being put in handcuffs and what else happen to me and much more.
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This is for those of you that don't know  how youtube works. I  need subscribers and likes and I need you to hit that bell also or people won't be able to find my video. Most most important watch the whole video.   
GA1 Stories & GA1 Research
The Icahn School of Medicine at Mount Sinai is an international leader in medical and scientific training, biomedical research, and patient care. The Department of Genetics and Genomics Sciences has been studying of inborn errors of metabolism for several decades leading to many scientific breakthroughs and the development of new therapies for patients. One of our current projects focusses on Glutaric Aciduria Type 1 (GA1). GA1 is caused by a defect in one of the (enzyme) steps in the breakdown of the amino acid lysine. Due to this defect specific breakdown products such as glutaric acid accumulate. This accumulation is thought to be harmful and the cause of the brain damage after a so-called acute encephalopathic crisis. Current treatment of GA1 aims to reduce lysine intake through a specific diet, and prevent encephalopathic crises through specific emergency measures during illness. Our research project on GA1 has 2 aims. To better understand the disease in particular which processes cause the brain damage Although our understanding of GA1 is very advanced, there are also some questions that remain unanswered. For example, although all experts believe that the brain damage is caused by the intolerable accumulation of metabolites derived from lysine breakdown, the exact identity of toxic molecule(s) is unknown. Also the process that leads to the brain damage is incompletely understood. Answering these questions is a very challenging problem, but the use of a GA1 animal model can help. Animal models are selected based on their resemblance to the human disease. In the case of GA1, there is a mouse model that displays many of the features of the human disease such lysine-induced brain damage. The use of a mouse model enables us to study aspects of GA1 that are impossible to address in human patients. To develop new treatment options that prevent the accumulation of harmful breakdown products through modulation of the lysine breakdown process There are humans with defects other than GA1 in the lysine breakdown process. Surprisingly some of these defects are considered not harmful. We are using this knowledge to investigate if we can manipulate lysine breakdown in GA1 patients in such a way that the accumulation becomes less harmful. For this research, we are using cells that have the same defect as GA1 patients. Ultimately, we will also use the mouse model. The ultimate goal of our research is to improve the lives of GA1 patients by increasing the knowledge about the disease and develop additional treatment options. n and set other styles.
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This is the new newsletter of Mayfield-Tv. It will be going out on Fridays It will contain the latest blog post and latest videos from the Mayfield-Tv site, my youtube channel and JKMGA1STORY. Since I'm coming out with new content 2 days a week I shouldn't have no problems coming out with a newsletter at the end of the week that being Fridays. If you want to go to my linktree go to
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This book is about a rare disorder called GA1. It is cause by to much protein build up in the body. This book is also about how I grow up with it.
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