Our new Synple Unity parallel synthesiser, controlled by a central terminal, allows the user to expand the number of module to reach the capacity they require. The system can be used for making small libraries of compounds biological testing or for screening a range of reaction conditions to identify the best synthetic route. Please get in touch for more information on Synple Unity: info@synplechem.com.

New biological tools provide new techniques to probe fundamental biological processes. One such class of tools are PROTACs, which offer the potential to greatly expand the druggable proteome.

Proteolysis targeting chimeras (PROTACs), consisting of two bioactive domains – one E3 ligase binder and one target protein binder – connected via a linker, can induce selective degradation of proteins and as such, offer a great deal of promise in the drug discovery field. Despite this, one of the major drawbacks is the lead time for PROTAC development, which can involve substantial synthetic and medicinal chemistry. We have developed a range of methods and cartridges, containing a range of partial PROTACs, which are capable of effecting PROTAC synthesis and purification in an automated manner.

This J. Med. Chem article offers a great analysis of how aliphatic fluorination affects, and can be used to modulate, lipophilicity.

Fluorine can play an important role in drug design and development. Introduction of a fluorine substituent into a drug molecule can influence a wide range of properties, including pKa, potency, permeability, metabolic liability, and structural conformation. Given its potential effects, there has been a strong drive towards the development of new synthetic methodologies that enable the facile introduction of fluorine at a late stage in the synthesis. Synple are aiming to take things even further and provide automated methods and cartridges for late-stage fluorination.

This year at the Automated Synthesis Forum, it was abundantly clear that synthetic organic chemistry is becoming increasingly automated, data rich and intelligent.This report highlights the progress both industry and academia are making in this field.